Eosinophilia with aberrant T cells and elevated serum levels of interleukin-2 and interleukin-15
The case of a 34-year-old man with eosinophilia is described. Eosinophilia is caused by excess levels of a white blood cell called eosinophils. The excess eosinophil levels can damage organs. Researchers also found excess levels of natural killer cells, as well as interleukin-15 and interleukin-2. The patient's symptoms may have been triggered by an infectious organism, which triggered the production of interleukin-15 and interleukin-2, which in turn triggered the activation of natural killer cells. The activated killer cells then produced proteins that stimulate eosinophil production.
Publication Name: The New England Journal of Medicine
Outcome analysis and cost assessment in immunologic disorders
Expensive biologic therapies for immune disorders may save treatment costs by reducing the rate of infections and hospitalizations. Chronic granulomatous disease causes lifelong risk of severe infections. Annual treatment with interferon gamma can cost about $20,000, but substantially reduces infections and can produce a net savings in medical costs. Intravenous immunoglobulin (IVIG) provides antibodies in patients with deficiency diseases. Despite substantial cost, IVIG may reduce bacterial pneumonia expenditures 81% in patients with agammaglobulinemia.
Publication Name: JAMA, The Journal of the American Medical Association