Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in rhesus macaque

Article Abstract:

Development of therapeutic agents for severe acute respiratory syndrome (SARS) viral infection using short interfering RNA (siRNA) inhibitors exemplifies a powerful new means to combat emerging infectious diseases. Potent siRNA inhibitors of severe acute respiratory syndrome (SARS) coronavirus (SCV) in vitro are further evaluated for efficacy and safety in a rhesus macaque.

Science & research, Research, Genetic aspects, RNA interference

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Good ACE, bad ACE do battle in lung injury, SARS

Article Abstract:

Angiotensin-converting enzyme 2 (ACE2) is useful for protection against lung injury caused by severe acute respiratory syndrome coronavirus (SARS-CoV). The conversion of angiotensin II to angiotensin 1-7 by ACE2 reduces angiotensin II binding to the cell membrane receptors angiotensin II type 1a receptor (AT1aR) and angiotensin II type 2 receptor (AT2R).

Health aspects, Usage, Prevention, Risk factors, ACE inhibitors, Angiotensin converting enzyme inhibitors, Lung diseases

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