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Viral nanoparticles as tools for intravital vascular imaging

Article Abstract:

A new strategy to use viral nanoparticles as a platform for the multivalent display of fluorescent dyes to image tissues deep inside living organisms is described. The intravital visualization of human fibrosarcoma-mediated tumor angiogenesis using fluorescent cowpea mosaic virus provides a means to identify arterial and venous vessels and monitors the neovascularization of the tumor microenvironment.

Author: Lewis, John D., Destito, Giuseppe, Zijlstra, Andries, Gonzalez, Maria, Quigley, James P., Manchester, Marianne, Stuhlmann, Heidi
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Cowpea, Diseases and pests, Host-virus relationships, Tumor antigens, Tumour antigens, Fibrosarcoma

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Quantitative imaging of plasmodium transmission from mosquito to mammal

Article Abstract:

A quantitative, real-time analysis of the fate of parasites transmitted in a rodent system is presented. Study revealed that only a proportion of the parasites enter the blood capillaries while others are drained by lymphatics.

Author: Menard, Robert, Shorte, Spencer, Amino, Rogerio, Thiberge, Sabine, Martin, Beatrice, Celli, Susanna, Frischknecht, Friedrich
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Control, Parasites, Lymphatics, Lymphatic system, Plasmodium, Plasmodium (Protozoa)

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Subjects list: Research, United States
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