Vulvar vestibulitis syndrome: a clinico-pathological study

Article Abstract:

Results are presented from evaluating 24 patients with vulvar vestibulitis syndrome, a condition involving severe vulvar pain when sexual intercourse is attempted; tenderness to pressure in the vestibule (opening) of the vagina; and redness of the vaginal vestibule. The patients, primarily white professional women aged 30 or younger, underwent examination of the vulva, with particular attention to dermatological abnormalities and microbiological analysis. Most had redness and tenderness of the vulva. Histopathological examination revealed signs of acute or chronic inflammation, with abnormal changes in the superficial cells. It is possible that the vulval vestibulitis syndrome is an end point for several different pathological processes, including infection, childbirth, or trauma. Patients with this condition need long-term follow-up, and should not be dismissed as neurotic simply because the causes of their problem are not yet known. (Consumer Summary produced by Reliance Medical Information, Inc.)

Case studies, Vulva, Vulvar diseases

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The fish-odor syndrome

Article Abstract:

The fish-odor syndrome results from the abnormal presence of large amounts of trimethylamine in the body caused by a genetic deficiency in a metabolic N-oxidation process. Trimethylaminuria, ichthyohidrosis and the consequent emanation of the offensive odor of decaying fish and psychosocial problems characterize the clinical picture. It becomes complex in the presence steroid hormones, precursor overload, dietary enzyme inhibitors and disease states. Treatment involves gene therapy, enzyme induction, acidic soaps and lotions and removal of precursors.

Analysis, Reports, Odors, Symptomatology, Signs and symptoms, Metabolic diseases

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The controversy over the classification of Gilles De La Tourette's syndrome, 1800-1995

Article Abstract:

The controversy between the classification and etiology of childhood movement disorders dominated the field of neurobiology throughout the 19th century. Clinical and historical evidence indicate an overlap of symptoms and similarity in predisposing causes in Tourette's syndrome, Sydenham's chorea and obsessive compulsive behaviors. An alternative approach based on predisposing causes needs further research on the cofactors that accompany such neurobiological disorders. The classification limits have so far hindered progress in this area.

Causes of, Pediatric diseases, Criticism and interpretation, Tourette's syndrome, Tourette syndrome, Movement disorders, Movement disorders in children, Chorea

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