Further evidence that the WT1 gene does not have a role in the development of the derivatives of the mullerian duct
The WT1 gene does not appear to be involved in the development of the female genital organs. The WT1 gene is so called because its absence causes Wilms' tumor, a kidney tumor. Researchers used DNA analysis to detect the presence or absence of WT1 gene mutations in 25 women with congenital absence of the uterus and vagina. No WT1 mutations were found in these women that could have caused this birth defect. This indicates that the WT1 gene is not involved in the formation of the embryonic structures that eventually form the uterus and vagina.
Publication Name: American Journal of Obstetrics and Gynecology
THE LIMITATIONS OF EVIDENCE(1)
Karl Popper's greatest contribution to the field of science was his belief that science is based on testable hypotheses, which may be reversed as new testable evidence emerges. Despite advances in these areas, in majority of acute situations, clinical medicine has limitations. There are illnesses that lead to death or incapacity.
Publication Name: Perspectives in Biology and Medicine
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