Aggregates in neurodegenerative disease: crowds and power?

Article Abstract:

Research on three neurodegenerative diseases reveal that molecular aggregates appear to somehow cause the death of neurons. A study on amyotrophic lateral sclerosis led to the the conclusion that superoxide dismutase-containing aggregates in neurons and strocytes contribute to the emergence of this neurodegenerative disease. On the other hand, some evidences are found that point to intranuclear aggregates and ubiquitin inducing Huntington's disease while intracytoplasmic Lewy bodies were found to trigger the appearance of the Parkinson's disease.

Causes of, Parkinson's disease, Parkinson disease, Huntington's chorea, Huntington's disease, Cell aggregation, Amyotrophic lateral sclerosis

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JAK/STAT eats the fat

Article Abstract:

Neurobiologists have reported that neuropeptide Y is the neurotransmitter responsible for inducing feeding behavior and that it is abundant in obese organisms. Another protein produced by adipose tissue, leptin, acts as a negative feedback loop and signals the brain so that mice will stop eating. The receptors for leptin have been identified and designated as Janus kinases. They bind with signal transducers and activators of transcription which initiate gene expression.

Research, Genetic aspects, Obesity, Food habits, Genetics, Neuropeptide Y

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Mitochondria - the Kraken wakes!

Article Abstract:

Several studies have shed light on the role of mitochondria in neurodegeneration, specifically cellular signal transduction. The activation of the mitochondrial permeability transition pore is observed to be related with mitochondrial swelling and osmotic changes. In addition, mitochondria has the propensity to leak reactive oxygen species such as superoxide and hydroxy free radicals.

Mitochondria

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