Avoiding another Vioxx: Guarding against unsafe drugs means major changes
Article Abstract:
Vioxx, an inflammatory drug is found to double the risk of heart attack and stroke on long-term use, which led to its withdrawal. Food and Drug Administration (FDA) orders drug companies to conduct post marketing research as a condition of approval. The FDA program, which gathers reports of adverse effects voluntarily submitted by doctors, has garnered criticism from prominent medical journals and epidemiologists for its underreporting and unreliability.
Publication Name: Scientific American
Subject: Science and technology
ISSN: 0036-8733
Year: 2005
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Doubt is their product
Article Abstract:
Industry groups sometimes manufacture uncertainty about solid scientific findings in order to fight off government regulation. Many companies that produce hazardous chemicals or drugs like phenylpropanolamine (PPA) and rofecoxib commonly known as Voxx have hired researchers to dispute and reanalyze data showing adverse health effects.
Publication Name: Scientific American
Subject: Science and technology
ISSN: 0036-8733
Year: 2005
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Register or Perish
Article Abstract:
The article examines efforts to bring negative results of clinical trials to public attention. Discussion focuses on the launch of a journal targeting these results, and laws requiring pharmaceutical companies to report their results in a database accessible by the general public.
Publication Name: Scientific American
Subject: Science and technology
ISSN: 0036-8733
Year: 2004
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