Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration
Article Abstract:
Notch signaling mediates many different intercellular communication events that are essential for determining the fates of neural and nonneural cells during the development and in the adult. The notch receptor is experimentally shown to act in a core pathway as a membrane-bound transcription factor that is released to the nucleus by a two-step cleavage mechanism called regulated intramembrane proteolysis (RIP).
Publication Name: Annual Review of Neuroscience
Subject: Science and technology
ISSN: 0147-006X
Year: 2003
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The nogo signaling pathway for regeneration block
Article Abstract:
The functional properties and signaling mechanism of myelin associated inhibitors of axon regeneration with an emphasis on a comparison of the mechanisms involved in developmental axon guidance is focused. The findings suggest the presence of inhibitory influences in the adult CNS environment.
Publication Name: Annual Review of Neuroscience
Subject: Science and technology
ISSN: 0147-006X
Year: 2004
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