Synthetic Diacyglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C)

Article Abstract:

Design and construction of a series of 4,4-disubstituted-gamma-butyrolactones are explained, which contain DAG-lactones that act selectively in activating ligands of protein kinase C (PK-C) in cellular signal transduction. The consequence of reducing the entropic penalty associated with the transformation of DAG to a DAG-lactone is examined.

Glycerol kinase

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Determinants of substrate recognition in nonreceptor tyrosine kinases

Article Abstract:

Tyrosine kinases are signaling enzymes that regulate growth, differentiation, and apoptosis in mammalian cells. The noncatalytic regions of Src family tyrosine kinases that are involved in enzyme regulation, substrate selection and multisite phosphorylation are described.

Chemical inhibitors

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Specificity is complex and time consuming: mutual exclusivity in tyrosine kinase-mediated signaling

Article Abstract:

Various protein complexes that appear during tyrosine kinase (TK)-mediated signaling are identified. TK-mediated signaling accounts for a large number of important transduction pathways in various fundamental cellular processes.

Similar abstracts:

• Abstracts: The raison D'etre of constitutively active protein kinases: the lesson of CK2. Chemical and mechanistic approaches to the study of Protein Tyrosine Phosphatases

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