The role of adenosine in promoting cardiac beta-adrenergic subsensitivity in aging humans

Article Abstract:

The role played by endogenous adenosine in the attenuation of the chronotropic response to beta-adrenoceptor stimulation due to aging is investigated. The results showed that theophylline caused the resting heart rate in elderly subjects to decrease, thus suggesting that the effects of theophylline on baroreceptor function are possibly dependent on age factors. This is the first indication that adenosine plays a role in the impaired isoproterenol chronotropic response.

Cardiovascular system, Circulatory system, Adenosine

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Influence of autonomic blockade and aging on AV conduction and responses to verapamil in the beagle

Article Abstract:

Analysis of age-induced variations in pharmacodynamic responses of beagles to verapamil, a calcium antagonist, reveals that older beagles exhibit longer atrioventricular (AV) conduction intervals, AV Wenckebach cycle and heart rate subsequent to pharmacologic autonomic blockade. Propranolol and atropine increased the influence of verapamil on diastolic blood pressure, AV conduction intervals and heart rate in younger beagles.

Dysautonomia, Verapamil, Beagles (Dogs)

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Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging

Article Abstract:

A comparative study of the pharmacologic responses of hypothalamic-pituitary-adrenocortical (HPA) axis to physostigmine, a cholinesterase inhibitor, in younger and older adults indicates that aging enhances HPA axis response to physostigmine. There is no variation in the levels of physostigmine in the plasma due to aging.

Hypothalamic-pituitary-adrenal axis, Physostigmine

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