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Hyperosmolarity causes BK(sub Ca)-dependent vasodilatations in rat skeletal muscle arteries

Article Abstract:

The vasodilatory effect of physiologically relevant increase in the extracellular osmolarity in isolated rat gluteal muscle arterioles is examined along with the underlying mechanisms of the hyperosmolarity (HO)-induced vasodilatations. Results show that an increase in the extracellular osmolarity elicits strong, fast, and long-lasting relaxations of rat skeletal muscle arterioles, and that vascular smooth BK(sub Ca) channels seem to play a crucial role in the HO-induced vasorelaxations.

Analysis, Physiological aspects, Water-electrolyte balance (Physiology), Fluid-electrolyte balance, Rats, Osmoregulation, Rattus

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Influence of progestin bioactivity on cutaneous vascular responses to passive heating

Article Abstract:

The skin blood flow during hyperthermia as a function of internal temperature gives information regarding the responsiveness of the system to changes in its major controller. It is found that, in women, control of the vasodilation is altered over the menstrual cycle or with oral contraceptives as part of an overall shift in thermoregulation to higher internal temperatures when progesterone and estrogen are elevated.

Diagnosis, Women, Women's health, Fever, Hyperthermia, Progestational hormones

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Hyperosmolarity increase K(super +)-induced vasodilations in rat skeletal muscle arterioles

Article Abstract:

Exercise hyperemia is mediated by a multitude of vasoactive metabolites released from the active skeletal muscle. The influence of hyperosmolarity (HO) on K(super +)-induced relaxation is investigated. The result shows that HO increases the sensitivity of the rat gluteal skeletal muscle arteries to the vasodilating effect of K(super +).

All Other Basic Inorganic Chemical Manufacturing, Potassium, Industrial inorganic chemicals, not elsewhere classified, Health aspects, Exercise, Muscles, Potassium (Chemical element), Skeletal muscle, Holmium

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