A brain-specific microRNA regulates dendritic spine development
Article Abstract:
A brain-specific microRNA, miR-134, is localized to the synapto-dendritic compartment of rat hippocampal neuron and negatively regulates the size of dendritic spines- postsynaptic sites of excitatory synaptic transmission. Exposure of neurons to extracellular stimuli such as brain-derived neutrophic factor relieves miR inhibition of Limk1 translation and may contribute to synaptic development, maturation and/or plasticity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Embracing the RNAissance
Article Abstract:
A new discovery about active role of RNA related with defense mechanism against genetic invasion from other organism, called RNA interference (RNAi) is described. RNAi became the hottest thing in science within years with companies rushing to help researchers design RNAs by providing reagents and kits for their gene-silencing endeavors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Silenced RNA on the move
Article Abstract:
Proteins are often produced at their site of action, but the RNAs from which they are made must be kept inactive until they reach the right spot. This strongly implies that there must be a tight coupling between RNA transport and repression of protein translation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Twists of fate in the brain. The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Asymmetrical threat averted
- Abstracts: Histone arginine methylation regulates pluripotency in the early mouse embryo. Role for sperm in spatial patterning of the early mouse embryo
- Abstracts: Brain imaging ready to detect terrorists, say neuroscientists. Adult suicides linked to popular antidepressant
- Abstracts: The effect of aggregates on interaction rate in ant colonies. Colony founding by pleometrosis in the semiclaustral seed-harvester ant Pogonomyrmex californicus
- Abstracts: Regulated cell-to-cell variation in a cell-fate decision system. Modelling cellular behaviour