A family of cytokine-inducible inhibitors of signalling

Article Abstract:

Cellular responses ,such as differentiation and proliferation, are regulated by cytokines, which activate members of the JAK family of cytoplasmic tyrosine kinases via receptor aggregation. An expression cloning technique has been used to clone a complementary DNA (cDNA) encoding a protein SOCS-1, that has been found to be related to other full-length cDNAs encoding related proteins, termed SOCS-2 and SOCS-3. Transcription of the SOC family suggests that they may regulate cytokine signal transduction.

Cancer research, Observations, Cancer, Cytokines, Cell research, Cytological research

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Polar gigantism dictated by oxygen availability

Article Abstract:

Maximum potential size of benthic amphipod crustaceans is restricted by oxygen availability, according to research using length data for 1,853 species from 12 sites worldwide. At all sites, size spectra are right-skewed, although skewedness rises as temperature falls. It was possible to identify strong links between external oxygen concentration and length, but not body mass. Maximum potential size rises significantly with oxygen, model size rises less and minimum size does not rise at all.

Animal development, Crustacea, Crustaceans

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Gigantism in mice lacking suppressor of cytokine signalling-2

Article Abstract:

Research is presented concerning the observation of mice unable to express cytokine signalling-2. The resultant gigantism affects bone length, organ size and weight and becomes evident after weaning.

Physiological aspects, Mice, Mice (Rodents), Genomes, Letter to the Editor

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