A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor

Article Abstract:

Alzheimer's disease and Down's syndrome (trisomy for chromosome 21) are related to extracellular deposition of amyloid beta-protein (beta-AP), also known as A4 protein. Attached inside the beta-AP region by a putative proteinase is the large membrane-bound precursor protein (APP) to expel the extracellular portion. Reverse zymography was used to study the matrix-degrading metalloproteinases in relation with the regulation of extracellular proteolysis of APP. It is shown that APP has a proteinase inhibitor domain which may be vital in formation of beta-AP.

Metalloproteins

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Short precursor shortens memory

Article Abstract:

Alzheimer's disease, in some cases, is due to the substitution of a gene base on chromosome 21, encoding the beta-amyloid precursor protein (APP). This results in an accumulation of deposits of amyloid beta-peptide. The amyloid beta-peptide sequence occurs partially outside a cell and within the membrane. Studies have shown that neural cells degenerate on expression of transmembrane fragment (C100), and work has found age-related neurodegeneration in the hippocampus of C100 mice

Alzheimer's disease

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

Article Abstract:

A metalloproteinase that cleaves precursor tumour-necrosis factor(TNF)-alpha from cells has been purified and cloned. Soluble TNF-alpha production was significantly reduced upon the inactivation of the gene in mouse cells. The enzyme, called the TNF-alpha converting enzyme, joins the family of mammalian adamalysins. The results are expected to aid in the development of therapeutically useful inhibitors of TNF-alpha release.

Metalloenzymes, Tumor necrosis factor

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