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Zoology and wildlife conservation

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A second catalytic metal ion in a group I ribozyme

Article Abstract:

All naturally occurring RNA enzymes need metal ions to stabilize their structure. Several divalent metals can provide structural roles in the self-splicing group I intron from Tetrahymena thermophila, although only Mg squared + and Mn squared + can promote splice-site cleavage and exon ligation. The first metal ion with a significant role in catalysis was revealed in a study of a ribozyme reaction analogous to 5-splice-site cleavage by guanosine.

Author: Cech, Thomas, Weinstein, Lara B., Jones, B.C.N.M., Cosstick, Richard
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
Proteins, RNA splicing

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RNA finds a simpler way

Article Abstract:

A bacterial gene regulation system with a twist to repress gene activity is described. The repressor is not a protein, but instead is a switchable self-cleavage element within the mRNA involving an RNA molecule with enzymatic activity.

Author: Cech, Thomas
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Science & research, Genetic aspects, Bacteria, RNA, Protein research

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Subjects list: Research
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