Abstracts - faqs.org

Abstracts

Zoology and wildlife conservation

Search abstracts:
Abstracts » Zoology and wildlife conservation

A telomerase component is defective in the human disease dyskeratosis congenita

Article Abstract:

Dyskerin was expressed with an HA-epitope tag or human telomerase reverse transcriptase component (hTERT) with a Flag-epitope tag through transient transfection of telomerase-positive human 293 cells, to determine if dyskerin is component of conventional H/ACA small nucleolar ribonucleoproteins and the human telomerase ribonucleoprotein. Dyskeratosis congenita (DKC) pathology is consistent with compromised telomerase function resulting in a defect in telomere maintenance.

Author: Mitchell, James R., Collins, Kathleen, Wood, Emily
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
Abnormalities, Epithelial cells, Dyskeratosis congenita

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein

Article Abstract:

The ciliate Tetrahymena thermophila as a model system was used to explore the mechanism for telomerase which is an essential cellular ribonucleoprotein (RNP) biogenesis. The experimental results show a hierarchical assembly mechanism for telomerase RNP in which the protein subunits mould a specific RNA tertiary structure in a stepwise fashion.

Author: Stone, Michael D., Collins, Kathleen, Xiaowei Zhuang, Mihalusova, Mariana, O'Connor, Catherine M., Prathapam, Ramadevi
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Science & research, RNA, Telomerase, Ribonucleoproteins

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

Article Abstract:

Telomerase is a key factor in the functioning of bone marrow, and research has found that bone marrow failure is linked to mutations affecting telomerase.

Author: Vulliamy, Tom, Marrone, Anna
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Bone marrow

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, Telomeres
Similar abstracts:
  • Abstracts: Assessment of pre-laying motivation in the domestic hen using social interaction. Social inhibition of movement in domestic hens
  • Abstracts: Germany aims for competitive equality. Germany says it will come on board Earth observation mission. New DFG head vows to back Germany's young scientists - and genetics research
  • Abstracts: An abrupt transition in colony founding behaviour in the ant Messor pergandei. Sex ratio determination by queens and workers in the ant Phedole desertorum
  • Abstracts: Costs of egg ventilation for male common gobies breeding in conditions of low dissolved oxygen. The influence of oxygen stress on female choice for male nest structure in the common goby
  • Abstracts: Global changes in intensity of the Earth's magnetic field during the past 800 kyr. Geomagnetic dipole strength and reversal rate over the past two million years
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2025 Advameg, Inc.