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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines

Article Abstract:

A transglutaminase (TGase) homologue, AdmF, has catalyzed the formation of the first amide bond, an N-acyl-[beta]-peptide link, in andrimid biosynthesis. Genome mining using the AdmF sequence has yielded additional TGases in unassigned natural product biosynthetic pathways, thus producing new classes of antibiotics.

Author: Walsh, Christopher T., Fortin, Pascal D., Magarvey, Nathan A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Science & research, Research, Antibiotics, Transglutaminases, Peptide bonds

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Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

Article Abstract:

The activity of five proteins, CmaA, CmaB, CmaC, CmaD, CmaE, in the construction of coronamic acid is reported. One of the results reveal that CmaC catalyses the formation of the cyclopropyl ring from the gamma-Cl-L-allo-isoleucine product of the CmaB reaction.

Author: Walsh, Christopher T., Vaillancourt, Frederic H., Yeh, Ellen, Vosburg, David A., O'Connor, Sarah E.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Analysis, Catalysis, Chemical structure

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