A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos
Article Abstract:
The prevention of activin signalling by a mutant activin receptor in Xenopus embryos confirmed that activin is essential for the growth of mesoderm in vivo and for configuration of the vertebrate body plan during embryonic development. Stopping the activin signal transduction pathway likewise demonstrated the autonomous induction of a neural marker and suggested that an activin pathway is needed for fibroblast growth factor signalling during mesoderm induction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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No muscles, but what a brain
Article Abstract:
The activins' contribution to the embryological development of the mesoderm and nervous tissue has been confirmed. Ali Hemmati-Brivanlou and Douglas A. Melton showed that activin molecules, such as the transforming growth factor-beta and the fibroblast growth factor, are essential parts of the mesodermal inducer in embryos of the amphibian Xenopus laevis. This finding may lead to greater knowledge of how the vertebrate body plan forms during embryonic growth.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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FGF-mediated mesoderm induction involves the Src-family kinase Laloo
Article Abstract:
Much of the body plan during embryogenesis is controlled by inductive interactions. A new study of Xenopus laevis identifies Laloo as a new participant that can induce posterior, ectopic axes. The embryonic function of Laloo is tested and provides strong evidence that an Src-family kinase plays a crucial part in early vertebrate development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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