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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Altered pain perception and inflammatory response in mice lacking prostacyclin receptor

Article Abstract:

The effect of the prostacyclin receptor PGI sub 2 was examined by disrupting the gene for the receptor in mice. The PGI sub 2-deficient mice seemed to behave normally, reproduce normally and had normal blood pressures. However, the tendency toward clotting of the blood increased in the receptor-deficient mice. The inflammatory and pain responses of the receptor-deficient mice also decreased to the level of that observed in wild-type mice treated with indomethacin. The study indicates that prostacyclin, which appears to have a role in reducing inflammation and pain, is an anti-clotting agent in vivo.

Author: Sugimoto, Yukihiko, Ushikubi, Fumitaka, Narumiya, Shuh, Tanaka, Takashi, Yoshida, Nobuaki, Matsuoka, Toshiyuki, Ichikawa, Atsushi, Murata, Takahiko, Hirata, Masakazu, Yamasaki, Atsushi, Aze, Yoshiya, Ueno, Akinori, Oh-ishi, Sachiko
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
Mice, Mice (Rodents), Prostacyclin, Prostanoids

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Role of citron kinase as a target of the small GTPase Rho in cytokinesis

Article Abstract:

Citron, a splice variant of a Rho target protein, contains a protein kinase domain that is connected with the Rho-associated kinases ROCK and ROK. These kinases control myosin-based contractility. ROCK does not seem to be vital for cytokinesis. However, the localization of citron to the cleavage furrow and the unusual movements produced by delta-1 during cell division suggest that this Rho effector plays a role in the contractile process of cytokinesis.

Author: Narumiya, Shuh, Matsuoka, Toshiyuki, Bito, Haruhiko, Ishizaki, Toshimasa, Madaule, Pascal, Eda, Masatoshi, Watanabe, Naoki, Fujisawa, Kazuko
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Cytokinesis

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Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP(sub3)

Article Abstract:

Fever is elicited by exogenous pyrogens, such as lipopolysaccharide (LPS). This stimulates the production of cytokines such as interluekin (IL)-1Beta. Aspirin-like anti-inflammatory drugs can suppress fever, and they can inhibit prostaglandin biosysthensis. Mice lacking prostaglandin E(sub2) receptor subtypes were generated, and only mice lacking EP(sub3) did not show a febrile response to PGE(sub2) and to either Il-1Beta or LPS.

Author: Sugimoto, Yukihiko, Ushikubi, Fumitaka, Yoshida, Nobuaki, Matsuoka, Toshiyuki, Ichikawa, Atsushi, Murata, Takahiko, Segi, Eri, Kobayashi, Takuya, Hazaki, Hiroko, Tuboi, Kazuhito, Katsuyama, Masato, Narumiya, Shu
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Observations, Prostaglandins, Fever, Pyrogens

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Subjects list: Research
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