An analgesia circuit activated by cannabinoids
Article Abstract:
Apparent pain-suppressing effects of delta-9-THC, the active constituent of marijuana, are confounded by motor deficits in animal studies. It is now shown that a brainstem circuit, contributing to morphine pain-suppressing effects, is also needed for the analgesic effects of cannabinoids. Analgesia is prevented by inactivation of the rostral ventromedial medulla (RVM). Cannabinoids produce analgesia through modulation of RVM neuronal activity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Vanilloid receptors on sensory nerves mediate the vasodilator action of annandamide
Article Abstract:
The effects of capsaicin and the selective calcitonin-gene-related peptide (CGRP)-receptor antagonist 8-37 CGRP on anandamide-induced relaxation in rate hepatic and small mesenteric arteries and guinea-pig basilar artery, were studied. Anandamide was found to activate vanilloid receptors on primary sensory neurons and is a possible molecular mechanism for the non-CBI receptor-mediated vasodilator action of anandamide.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Article Abstract:
The molecular mechanism of isothiocyanates is studied through various experiments. It is concluded that, mustard oil depolarizes a subpopulation of primary sensory neurons.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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