Analysis fo telomere lengths in cloned sheep
Article Abstract:
Animals can be produced without involving germline cells, with the development of nuclear-transfer technology using cultured somatic cells. The telomere lengths of animals 6LL3 (Dolly), 6LL6 and 6LL7 have been compared with age-matched control sheep, donor mammary gland tissue and donor cells before and after culturing, to examine whether telomere erosion is repaired following nuclear transfer. The mean terminal restriction fragment (TRF) sizes were smaller in each of the nuclear-transfer animals than the controls, with DNA in 6LL3 showing the highest diminution of mean TRF. There were no major differences in the DNA of the six year old progenitor mammary tissue and age-matched control DNA from fresh blood.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Flexible arrangement
Article Abstract:
The dogma of unidirectional, hierarchical cell lineages in tissue development, maintenance and repair is explained by the action of irreversible gene restrictions. Elucidation of all of the mechanisms that regulate developmental potential will allow us to discover the true limits of cell plasticity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Primates join the club
Article Abstract:
The generation of stem-cell lines from embryos of rhesus macaques by applying a modified somatic cell nuclear transfer (SCNT) protocol is reported. The research finding could provide insight into several diseases in humans.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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