Another role rolls in

Article Abstract:

The retinoblastoma tumor-suppressor protein (Rb) inhibits the activity of genes transcribed by Pol III in cultured primary mouse fibroblasts. Thus, Rb regulates cellular biosynthesis by controling rRNA and tRNA genes. Rb also controls cell division by regulating division suppressing factors such as E2F. The control of biosynthesis by Rb explains the proliferation of cells with mutant Rb. Cell proliferation requires de-regulation of both cell cycle and cellular biosynthesis as biosynthesis is independent of cell division in animal cells.

Physiological aspects, Proteins, Biosynthesis, Tumor suppressor genes, Cell proliferation

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Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle

Article Abstract:

It is shown that the two kinetochores of engineered, unreplicated dicentric chromosomes in Saccharomyces cerevisiae bi-orient efficiently and also that Ipl1 (Aurora B in animal cells) facilitates bi-orientation by promoting the turnover of kinetochore-spindle pole connections in a tension-dependent manner.

Science & research, Influence, Protein kinases, Anaphase, Kinetochores

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Molecular mechanisms of kinetochore capture by spindle microtubules

Article Abstract:

The individual kinetochore-microtubule interactions in Saccharomyces cerevisiae are visualized by regulating the activity of a centromere . It is found that the microtubule extension from spindle poles requires microtubule plus-end-tracking proteins and Ran GDP/GTP exchange factor (GEF).

Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Observations, Microtubules, Brewer's yeast, Saccharomyces cerevisiae, Structure

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