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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Apoptosis of T cells mediated by galectin-1

Article Abstract:

Stimulation of apoptosis of activated human T cells and human T leukemia cell lines involves galectin-1 . Resting T cells can bind to galectin-1 but are unaffected. Endothelial cells that produce galectin-1 can cause apoptosis of bound T cells. Cell death by galectin-1 requires the expression of CD45. The blockage of N-glycan elongation by treatment of the cells with swainsonine decreases galectin-1-induced apoptosis. The effects of galectin-1 represent a novel mechanism for immune response regulation.

Author: Perillo, Nancy L., Pace, Karen E., Seilhamer, Jeffrey J., Baum, Linda G.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
Physiological aspects, Lectins, Immune response, Immune response regulation

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Apoptosis in development

Article Abstract:

The way in which certain model organisms of developmental biology have contributed to the understanding of cell death in development and homeostasis, is discussed.

Author: Evan, Gerard, Meier, Pascal, Finch, Andrew
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Homeostasis

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From bench to clinic with apoptosis-based therapeutic agents

Article Abstract:

Apoptosis-based therapeutic agents are discussed.

Author: Nicholson, Donald W.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Diseases

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Subjects list: Research, Cell death
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