Apoptosis of T cells mediated by galectin-1
Article Abstract:
Stimulation of apoptosis of activated human T cells and human T leukemia cell lines involves galectin-1 . Resting T cells can bind to galectin-1 but are unaffected. Endothelial cells that produce galectin-1 can cause apoptosis of bound T cells. Cell death by galectin-1 requires the expression of CD45. The blockage of N-glycan elongation by treatment of the cells with swainsonine decreases galectin-1-induced apoptosis. The effects of galectin-1 represent a novel mechanism for immune response regulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Apoptosis in development
Article Abstract:
The way in which certain model organisms of developmental biology have contributed to the understanding of cell death in development and homeostasis, is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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From bench to clinic with apoptosis-based therapeutic agents
Article Abstract:
Apoptosis-based therapeutic agents are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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