CIC chloride channels viewed through a transporter lens
Article Abstract:
The CIC family of chloride channels not only features genuine chloride channels, but also includes proton-coupled chloride transporters, which move chloride ions and protons across the membrane in opposite directions. The crystal structure of proton-coupled chloride transporters serves as a useful platform for understanding CIC channels, and features of chloride/proton exchange-transport may provide understanding of voltage-dependent gating of the channels.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Secondary active transport mediated by a prokaryotic homologue of ClC Cl (super -) channels
Article Abstract:
ClC Cl (super -) channels make up a large molecular family, ubiquitous with respect to both organisms and cell types. It seems that the structural boundary separating channels and transporters is not clear-cut because the same molecular architecture supports two fundamentally different transport mechanisms.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Coughing up flu's proton channels
Article Abstract:
The X-ray crystallographic and NMR spectroscopic studies of the influenza virus are reported. The findings provide insight into membrane-bound hydrogen-ion channel of virus necessary for infection and virulence.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
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