Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor

Article Abstract:

The analgesic effect of opioids primarily activates the mu-opioid receptor but has a similar effect on the kappa-receptor, whose role is less clear. While kappa-receptors produce analgesia, they are also found to antagonize morphine analgesia. New research shows that the activation of the kappa-receptor specifically antagonizes analgesia induced by the mu-receptor. The finding suggest new approaches to the treatment of opioid addiction and pain control.

Physiological aspects, Opioids, Opioid receptors, Endorphins

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The rise of neurogenetic determinism

Article Abstract:

Reductionist interpretations of advances in neuroscience hamper the application of available neuroscientific knowledge in human interests. Neuroscientific advances have improved the perception of brain and behavior and possess the potential to attenuate human suffering. Hence, an unidirectional understanding of these advances should be replaced with integrated understanding of the relationship between biological, personal and social issues.

Influence, Reductionism

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