Chemokines and leukocyte traffic
Article Abstract:
Significant progress has been made during the 1990s in identifying chemokines as attractants of various types of blood leukocytes to sites of infection and inflammation. Lymphocytes are likely to be a key element of future progress in this area, and it seems very probable that most migration responses in the complex trafficking of lymphocytes of various types and degrees of activation will eventually prove to be mediated by chemokines. Research in this area will offer therapeutic opportunities for transplantation, autoimmune diseases and immune deficiencies.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
Article Abstract:
P-selectin, a glycoprotein, influences the congregation of leukocytes and platelets required to form a thrombus or blood clot. P-selectin is a cell adhesion molecule that controls the interaction of two types of leukocyte, monocytes and neutrophils, with platelets and endothelial cells. Experimental work with the thrombi of baboons added many details to the process by which P-selectin effects leukocyte-platelet adhesion, for instance by inducing the leukocytes to cause the formation of fibrin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1
Article Abstract:
Soluble endothelial adhesion molecules may function as mediators of angiogenesis suggesting novel roles for soluble E-selectin and soluble vascular-cell-adhesion molecule-1 (VCAM-1) in angiogenesis. E-selectin and VCAM-1 may be shed by endothelial cells when leukocytes bind to the cells, and then they may bind to adjacent cells which would mediate inflammation. The result points to a link between cellular adhesion and angiogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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