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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Clonal selection and learning in the antibody system

Article Abstract:

Antibody-producing B cells and somatically mutated memory cells use cell proliferation along with stringent cellular selection for production and survival of cells of the desired specificity. Antibody-producing B cells generate antibodies of unique specificity in a series of ordered gene rearrangements. Another selection during immune responses produces a series of antibodies through somatic hypermutation. Both the processes use antigen-mediated negative selection to avoid self-reactivity. The unselected cells die most probably by apoptosis.

Author: Rajewsky, Klaus
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
Cell death, Antibody diversity

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Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice

Article Abstract:

The activation of B-cells by the T-cell-dependent antigens as well as the maturation and selection of the cells into the memory compartment requires the antigen CD19, which is a differentiation antigen in the B-cells. The development of conventional B-cells is not impaired in CD19 deficient mice but mature CD19(super -/-) B cells are unable to bind to T-cells and there is no germinal center formation and maturation of serum antibodies.

Author: Rajewsky, Klaus, Rickert, Robert C., Roes, Jurgen
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995

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Burnet's unhappy hybrid

Article Abstract:

Genetic research scientist F.M. Burnet concluded that B lymphocyte cells establish antigen receptor specificity prior to antigen stimulation. Modern genetic research suggests that B lymphocyte cells modify antigen receptor specificity in response to antigen stimulation via somatic hyperpointmutation. Burnet's work concluded that V(D)J recombination in B-cell development was a distinct acceptable possibility.

Author: Rajewsky, Klaus
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Antigenic determinants, Burnet, F.M.

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Subjects list: Research, B cells, Cell differentiation
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