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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

Article Abstract:

Replication-incompetent adenovirus serotype 5 (rAd5) vectors were engineered to circumvent anti-Ad5 immunity. It was observed that chimaeric viral vectors were engineered to circumvent pre-existing anti-vector immunity by removing key neutralizing epitopes on the surface of viral capsid proteins that have important practical implications for vaccination and gene therapy.

Author: Chen, Bing, Goudsmit, Jaap, Mansfield, Keith G., Gorgone, Darci A., Lifton, Michelle A., Roberts, Diane M., Nanda, Anjali, Havenga, Menzo J.E., Abbink, Peter, Lynch, Diana M., Ewald, Bonnie A., Liu, Jinyan, Thorner, Anna R., Swanson, Patricia E., Lemckert, Angelique A.C., Holterman, Lennart, Dilraj, Athmanundh, Carville, Angela, Barouch, Dan H.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Science & research, Drug therapy, Human immunogenetics, Virus-vector relationships, Vector-borne diseases

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Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

Article Abstract:

Three attenuated Mycobacterium tuberculosis mutants were isolated used signature-tagged mutagenesis. They cannot synthesize or transport phthiocerol dimycocerosate (PDIM). Two mutants had transposon insertions affecting genes implicate din PDIM synthesis, while the third has a disruption in a gene encoding transmembrane proteins need for subcellular localization of PDIM.

Author: Chen, Bing, Cox, Jeffery S., McNeil, Michael, Jacobs, William R.Jr.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999

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Persistence of Mycobacterium tuberculosis in macrophages and mice requires glyoxylate shunt enzyme isocitrate lyase

Article Abstract:

Research into the ability of Mycobacterium tuberculosis to persist for prolonged periods shows that the absence of the gene for isocitrate reduces the pathogen's survival rates in some circumstances.

Author: McKinney, John D., zu Bentrup, Kerstin Honer, Munoz-Elias, Ernesto J., Miczak, Andras, Chen, Bing, Chan, Wai-Tsing, Swenson, Dana, Sacchettini, James C., Jacobsm William R., Jr., Russell, David G.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Prevention, Tuberculosis

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Subjects list: Research, Mycobacterium tuberculosis
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