Controlling the cellular brakes
Article Abstract:
It has been established that molecular brakes, which are believed to play a key role in cell differentiation, are very important for correct development of the neuronal system and new blood vessels. It was also found that endothelial cells switch on the differentiation brakes during tumour angiogenesis. If the brakes could be manipulated, then it may be possible to block angiogenesis, and thus tumour formation. This work is also relevant to the issue of how adult endothelial cells, after being quiescent for a long time, may suddenly become extremely proliferative when angiogenesis is reinitiated during pathological conditions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Organizing the cerebrum
Article Abstract:
Hypotheses regarding the development of the organization of the cerebral cortex in primates are discussed. The cerebral cortex sits on top of the rest of the forebrain, and although it is essentially a single sheet of tissue, its various areas are dedicated to specific functions. One hypothesis, the radial unit hypothesis, states that the organization into functional patches is already present in the ventricular zone, comprised of the precursor cells that give rise to the cortical neurons and glia. An alterative hypothesis states that the organization is induced by later influences from adjacent brain regions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch
Article Abstract:
A study of the roles of Drosophila shaggy kinase and rat glycogen synthase kinase-3 (GSK-3) during neurogenesis is presented. During neurogenesis in Drosophila, equipotential cells choose between epidermal and neural fates based on the activity of the phylogenetically conserved transmembrane protein called Notch, which acts as a receptor in a lateral signalling pathway for fate determination. The results showed that shaggy kinase and GSK-3 have similar actions in intracellular signal transduction downstream of Notch .
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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