Correlation of expression of Wnt-1 in developing limbs with abnormalities in growth and skeletal patterning

Article Abstract:

A study of the correlation between the expression of Wnt-1 in developing limbs with abnormalities in growth and skeletal patterning is presented. The Wnt-1 genes encode proteins that are responsible for patterning and growth control during limb budding and morphogenesis. The study involved a transgenic mouse line which ectopically expresses Wnt-1 in the developing limb. Transgenic mice exhibited congenital limb malformations characterized by extensive distal truncations, skeletal fusions and interdigital webbing. These were correlated with abnormal mesenchymal condensations leading to abnormal skeletal development.

Cell differentiation, Ontogeny

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Synpolydactyly in mice with a targeted deficiency in the HoxD complex

Article Abstract:

The loss of function of various HoxD genes in the limb buds of mice are responsible for the HOXD13 associated synpolydactyly. The deficiency of this gene leads to a small digit primordia, and a damaged skeletal mass and cartilage pattern. The position of the gene in the HoxD complex determines the stimulation of a given HoxD gene in the limbs during development. The deficiency has important implications for the study of human digit malformations and the pathogenesis of synpolydactyly in humans.

Physiological aspects, Gene mutations, Gene mutation, Mammals

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Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function

Article Abstract:

A description of mice that are lacking all HoxA and HoxD functions in their forelimbs is presented. A demonstration that such limbs are arrested early in their developmental patterning and display severe truncations of distal elements, partly owing to the absence of Sonic hedgehog expression is presented.

United States, Science & research, Gene expression, Hedgehogs

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