Small self-RNA generated by RNase L amplifies antiviral innate immunity
Article Abstract:
The activation of the antiviral endoribonuclease (RNase L) by 2',5'-linked oligoadenylate (2-5A) has produced small RNA cleavage products from self-RNA that has initiated interferon (IFN). The results have shown that RNase L has played a vital role in the innate antiviral immune response that relives the requirement for direct sensing of non-self RNA.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
RNA, Immune response, Immune response regulation
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Interferon modulation of cellular microRNAs as an antiviral mechanism
Article Abstract:
Study is presented which demonstrates that IFN[alpha]/[beta] upregulates several cellular miRNAs that are capable of inhibiting hepatitis C virus (HCV) replication and infection.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Genetic aspects, Genetic transcription, Transcription (Genetics), DNA microarrays, Hepatitis C virus, RNA interference
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Subjects list: Research, Interferon
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