The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Article Abstract:

Research is presented concerning the delays which are caused in the progression of the cell cycle in eukaryotic cells which have been subjected to ionizing radiation. The significance for cancer-prone patients is discussed.

Cancer, Radiotherapy, Cell cycle, Letter to the Editor

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Are all cancer genes equal?

Article Abstract:

Issues are presented concerning the physiological changes in particular classes of genes which result in cancer. The resistance of mice deficient in the cyclin D1 gene to certain forms of breast cancer is discussed.

Genetic aspects, Breast cancer, Mice, Mice (Rodents)

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Article Abstract:

The incipient tumour experiences oncogenic stress during the evolution of cancer, which evokes counter-responses to eliminate such hazardous cells. The study shows that the early precursor lesions (but not normal tissues) commonly express markers of an activated DNA damage response in clinical specimens from different stages of human tumours of the urinary bladder, breast, lung, and colon.

Science & research, Research, DNA damage, Oncogenes

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