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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Article Abstract:

Tyrosyl phophodiesterase 1 (TDP1) is required for repair of chromosomal single-strand breaks in human cells arising independently of DNA replication from abortive top1 activity or oxidative stress. It is reported that TDP1 is sequestered into multi-protein single-strand break repair (SSBR) complexes by direct interaction with DNA ligase IIIalpha and that these complexes are catalytically inactive in spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) cells.

Author: Weinfeld, Michael, Caldecott, Keith W., Lupski, James R., Helleday, Thomas, El-Khamisy, Sherif F., Saifi, Gulam M., Johansson, Fredrik
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Axons, Oxidative stress, Spinocerebellar ataxia

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Completing the map of human genetic variation

Article Abstract:

The National Human Genome Research Institute (NHGRI) has launched a community resource project that sequences large-insert clones from many individuals, systematically discovering and resolving the complex variants at the DNA sequence level. The sequence resolution of both single-nucleotide and larger-scale genomic variants will help in understanding the natural variation in human populations and the link between genetics and human health.

Author: Altshuler, David, Bowcock, Anne M., Eichler, Evan E., Lee, Charles, Smith, Douglas, Valle, David, Lupski, James R., Sherry, Stephen T., Nickerson, Deborah A., Church, Deanna M., Carter, Nigel P., Pritchard, Jonathan K., Waterson, Robert H., Brooks, Lisa D., Felsenfeld, Adam, Guyer, Mark, Mullikin, James C., Sebat, Jonathan
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Genetic aspects, Nucleotide sequence, Base sequence, Drosophila, Genetic variation

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Article Abstract:

A study conducted shows that poly(ADP-ribose) polymerase (PARP1) inhibitors trigger gamma-H2AX and RAD51 foci formation. It proposes that, in the absence of PARP1, spontaneous single-strand breaks collapse replication forks and trigger homologous recombination for repair.

Author: Bryant, Helen E., Schultz, Niklas, Thomas, Huw D., Parker, Kayan M., Flower, Dan, Lopez, Elena, Kyle, Suzanne, Meuth, Mark, Curtin, Nicola J., Helleday, Thomas
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Breast cancer, DNA repair, Polymerase chain reaction

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Subjects list: Research, United States, Analysis
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