Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
Article Abstract:
Tyrosyl phophodiesterase 1 (TDP1) is required for repair of chromosomal single-strand breaks in human cells arising independently of DNA replication from abortive top1 activity or oxidative stress. It is reported that TDP1 is sequestered into multi-protein single-strand break repair (SSBR) complexes by direct interaction with DNA ligase IIIalpha and that these complexes are catalytically inactive in spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Completing the map of human genetic variation
Article Abstract:
The National Human Genome Research Institute (NHGRI) has launched a community resource project that sequences large-insert clones from many individuals, systematically discovering and resolving the complex variants at the DNA sequence level. The sequence resolution of both single-nucleotide and larger-scale genomic variants will help in understanding the natural variation in human populations and the link between genetics and human health.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Article Abstract:
A study conducted shows that poly(ADP-ribose) polymerase (PARP1) inhibitors trigger gamma-H2AX and RAD51 foci formation. It proposes that, in the absence of PARP1, spontaneous single-strand breaks collapse replication forks and trigger homologous recombination for repair.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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