Designed divergent evolution of enzyme function

Article Abstract:

The construction of seven specific and active synthases is presented that use different reaction pathways to produce the specific and very different products. Creation of these enzymes demonstrates the feasibility of exploiting the underlying evolvability of the scaffold and provides evidence that rational approaches are useful for enzyme design.

All Other Basic Organic Chemical Manufacturing, Enzymes for Food Processing, Health aspects, Enzyme therapy

---

Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast

Article Abstract:

The causes of the gene dispensability in yeast are investigated and the metabolic capabilities of a network are calculated. The results indicate that the dosage requirements have an important influence on the evolutionary maintenance of gene duplicates in yeast.

Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Yeast, Yeast (Food product), Chemical properties

---

Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template

Article Abstract:

CC-adding enzymes add specific nucleotides in the absence of a nucleic acid template. The model that explains how enzyme incorporates CTP and ATP with high specificity is proposed.

Transfer RNA, DNA microarrays

Similar abstracts:

• Abstracts: Regulation of p53 activity through lysine methylation. Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase
• Abstracts: Evolution of the continental crust. Metal saturation in the upper mantle
• Abstracts: Polymerization within a molecular-scale stereoregular template. The RickA protein of Rickettsia conorii activates the Arp2/3 complex
• Abstracts: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum
• Abstracts: Visualizing dislocation nucleation by indenting colloidal crystals. In situ observation of colloidal monolayer nucleation driven by an alternating electric field

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.