Designed divergent evolution of enzyme function
Article Abstract:
The construction of seven specific and active synthases is presented that use different reaction pathways to produce the specific and very different products. Creation of these enzymes demonstrates the feasibility of exploiting the underlying evolvability of the scaffold and provides evidence that rational approaches are useful for enzyme design.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast
Article Abstract:
The causes of the gene dispensability in yeast are investigated and the metabolic capabilities of a network are calculated. The results indicate that the dosage requirements have an important influence on the evolutionary maintenance of gene duplicates in yeast.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template
Article Abstract:
CC-adding enzymes add specific nucleotides in the absence of a nucleic acid template. The model that explains how enzyme incorporates CTP and ATP with high specificity is proposed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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