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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Different beta-subunits determine G-protein interaction with transmembrane receptors

Article Abstract:

The regulatory GTP-binding proteins (G proteins) consist of alpha, beta and gamma membrane-attached heterotrimer subunits. The beta-1 and beta-3 subtypes have now been shown to help control the signal transduction cascade from muscarinic M4 and somatostatin receptors to voltage-dependent calcium 2+ channels. Discovery of the beta subunits' role in inducing G-protein to react with transmembrane receptors is the first significant progress in establishing the subunits' physiological function.

Author: Kleuss, C., Scherubl, H., Hescheler, J., Shultz, George P., Wittig, B.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
Cell receptors

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Association between GTPase activators for Rho and Ras families

Article Abstract:

The recombinant p190 protein resembles the GTPase activating proteins (GAPs) most particularly in acting as a GAP rho protein. This finding was obtained by performing GAP assays on 14 purified GTPases. Hence the formation of a complex involving the Ras-GAP and p190 in growth-factor simulated cells may permit the coupling of signalling pathways with the ras and rho GTPases. The GAP activity of p190 results from DNA sequences common to the breakpoint cluster region.

Author: Weinberg, Robert A., Settleman, Jeffrey, Albright, Charles F., Foster, Lauren C.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992

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C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a

Article Abstract:

Experiment shows that G-protein-coupled receptor (GPCR) C5L2 is required for effective modulation of C5a and C3a for anaphylatoxin induced responses and its deficiency affects anti-inflammatory responses.

Author: Wen-Chen Yeh, Nien-Jung Chen, Mirtsos, Christine, Suh, Daniel, Yong-Chen Lu, Wen-Jye Lin, McKerlie, Colin, Taeweon Lee, Baribault, Helene, Hui Tian
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
United States, Science & research, Immune response, Immune response regulation, Report

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Subjects list: Research, Cellular signal transduction, G proteins
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