Direct charging of tRNA sub(CUA) with pyrrolysine in vitro and in vivo

Article Abstract:

Studies done to demonstrate that synthetic L-pyrrolysine is attached as a free molecule to tRNA (sub CUA) by PylS, an archaeal class II aminoacyl-tRNA synthetase is reported. This is the first example from nature of direct aminoacylation of a tRNA with a non-canonical amino acid and demonstrates that the genetic code of Escherichia coli can be expanded to include UAG-directed pyrrolysine incorporation into proteins.

Pyrrole, Pyrroles

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Nanoarchaeum equitans creates functional tRNAs from separate genes for their 5'- and 3'-halves

Article Abstract:

An extensive search of the available bacterial and archaeal genome sequences did not reveal split tRNA genes in other organisms. Future sequences of other very small or compact genomes should reveal whether split tRNA genes are signs of a very early genome or whether they are created in a later process of genome size reduction.

United States, Nucleotide sequencing

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Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA

Article Abstract:

The structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA is discussed.

RNA splicing, Introns

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