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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Epithelial-cell-intrinsic IKK-[beta] expression regulates intestinal immune homeostasis

Article Abstract:

The Trichuris muris infection model was employed to investigate the role of intestinal epithelial cells (IECs) in regulating CD[4.sup.+] T-cell-mediated immunity and inflammation in the gastro-intestinal (GI) tract. The results indicate that the balance of I[kappa]B kinase (IKK)-[beta]-dependent gene expression in the intestinal epithelium is crucial in intestinal immune homeostasis by promoting mucosal immunity and limiting chronic inflammation.

Author: Karin, Michael, Greten, Florian R., Eckmann, Lars, May, Michael J., Gruber, Achim D., Zaph, Colby, Troy, Amy E., Taylor, Betsy C., Berman-Booty, Lisa D., Guild, Katherine J., Du, Yurong, Yost, Evan A., Artis, David
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Intestines, Intestinal microbiology, Epithelial cells

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The protein kinase PKR is required for macrophage apoptosis after activation of toll-like receptor 4

Article Abstract:

The anthrax bacterium selectively induces apoptosis of activated macrophages through its lethal toxin, which prevents activation of the anti-apoptotic p38 mitogen-activated protein kinase. The macrophage apoptosis by three different bacterial pathogens depends on activation of TLR4 is demonstrated.

Author: Karin, Michael, Kaufman, Randal J., Li-Chung Hsu, Park, Jin Mo, Zhang, Kezhong, Luo, Jun Li, Maeda, Shin, Eckmann, Lars, Guiney, Donald G.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Bacteria, Macrophages, Protein kinases

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I(sub k)B kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis

Article Abstract:

The major site of Ikk-alpha action on basal keratinocyte of the epidermis exhibited by Ikka mice is examined. The human Ikka transgene driven by the basal keratinocyte-specific promoter of the cytokeratin was used for testing this hypothesis.

Author: Karin, Michael, Maeda, Shin, Sil, Alok K., Sano, Yuji, Roop, Dennis R.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Morphogenesis, Epidermis

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Subjects list: Research
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