Evidence for cooperative interactions in potassium channel gating
Article Abstract:
The gating of the potassium ion channels (K+-channels) occurs cooperatively between the different subunits instead of separately. This was determined by constructing complementary DNA for the four subunits and specifying the subunit stoichiometry on a single polypeptide chain. The gating of heterotetramers composed of combinations of subunits indicated that the subunits open up together rather than independently. Nonindependent gating agrees with what is known about K+-channel kinetics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation
Article Abstract:
Atrial natriuretic peptide (ANP) uses protein dephosphorylation to initiate calcium- and voltage-activated potassium channel (BK) activity in GH4C1 cells. In addition, ANP differs from another natriuretic peptide, somatostatin, by requiring cyclic guanosine monophosphate (cGMP) and cGMP-dependent protein kinase activity before BK can start to function. Hence ANP regulates electrophysiology by limiting calcium channels in favor of BK.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Fifty years of inactivation
Article Abstract:
New research, revealing the events involved in the closure of potassium channels, known as inactivation, is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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