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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Evolving concepts of rheumatoid arthritis

Article Abstract:

This article reviews the origin of rheumatoid arthritis, its pathogenesis, and the immunological aspects. The most common inflammatory arthritis existed in early Naive American populations but surfaced in Europe only in 17th century. The author discusses and elaborates on the involvement of autoantibodies and immune complexes in the pathogenesis of rheumatoid arthritis along with some possible therapeutic interventions.

Author: Firestein, Gary S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Autoantibodies, Physiological aspects, Rheumatoid arthritis, Rheumatic diseases, Immunologic diseases

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

Article Abstract:

A study is conducted describing experiments with a genetically modified mouse in which the catalytic domain of a disintegrin and metalloproteinase with thrombospondin (ADAMTS)5 was deleted. The results demonstrate that ADAMTS5 is the primary aggrecanase responsible for aggrecan degradation in a murine model of osteoarthritis, and suggest rational strategies for therapeutic intervention in osteoarthritis.

Author: Sheppard, Barbara, Glasson, Sonya S., Blanchet, Tracey, Flannery, Carl R., Kanki, Kim; Zhiyong Yang;, Askew, Roger, Carito, Brenda, Hak-Ling Ma, Peluso, Diane, Majumdar, Manas K., Morris, Elisabeth A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Osteoarthritis

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Article Abstract:

A disintegrin and metalloproteinase with thrombospondin (ADAMTS) 5 is the major aggrecanase in mouse cartilage, both in vitro and in a mouse model of inflammatory arthritis. Data suggest that ADAMTS5 may be a suitable target for the development of new drugs designed to inhibit cartilage destruction in arthritis.

Author: Stanton, Heather, East, Charlotte J., Lawlor, Kate E., Little, Christopher B., Farmer, Pamela J., Rogerson, Fraser M., Golub, Suzanne B., Meeker, Clare T., Last, Karena, Campbell, Ian K., Fourie, Anne M., Fosang, Amanda J.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Drug therapy

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Subjects list: Research, United States, Arthritis, Genetic aspects
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