Evolving concepts of rheumatoid arthritis
Article Abstract:
This article reviews the origin of rheumatoid arthritis, its pathogenesis, and the immunological aspects. The most common inflammatory arthritis existed in early Naive American populations but surfaced in Europe only in 17th century. The author discusses and elaborates on the involvement of autoantibodies and immune complexes in the pathogenesis of rheumatoid arthritis along with some possible therapeutic interventions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
Article Abstract:
A study is conducted describing experiments with a genetically modified mouse in which the catalytic domain of a disintegrin and metalloproteinase with thrombospondin (ADAMTS)5 was deleted. The results demonstrate that ADAMTS5 is the primary aggrecanase responsible for aggrecan degradation in a murine model of osteoarthritis, and suggest rational strategies for therapeutic intervention in osteoarthritis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
Article Abstract:
A disintegrin and metalloproteinase with thrombospondin (ADAMTS) 5 is the major aggrecanase in mouse cartilage, both in vitro and in a mouse model of inflammatory arthritis. Data suggest that ADAMTS5 may be a suitable target for the development of new drugs designed to inhibit cartilage destruction in arthritis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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