Exhausted T cells perk up

Article Abstract:

Study is conducted to demonstrate that a receptor-ligand pair involved in controlling the immune response can be blocked by antibodies to revive dysfunctional T cells and clear a chronic viral infection. Following many infections, immune cells that recognize antigens from the invading pathogens undergo a dramatic expansion in number and develop functions to deal with the intruders.

Care and treatment, Virus diseases

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Tied T cells turn around

Article Abstract:

Chronic infections such as those caused by hepatitis viruses B and C and the human immunodeficiency virus HIV-1 prompt a massive cellular immune response, but eventually tire the immune cells, with varying degrees of impairment of their effector functions. Scientists show how blocking the activation of a cell receptor called PD-1might restore these exhausted cells.

Physiological aspects, Chronic diseases, Cell receptors

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Interleukin-2 signals during priming are required for secondary expansion of CD[8.sup.+] memory T cells

Article Abstract:

Interleukin-2 (IL-2) signaling to pathogen-specific CD[8.sup.+] T cells hardly affects the number of developing effector and memory cells, but it is required for the generation of robust secondary responses. The results have important significance for the development of vaccination or immunotherapeutic strategies aimed at boosting memory T-cell function.

Health aspects, Analysis, Usage, Flow cytometry, Cell proliferation, Interleukin-2, Rats as laboratory animals, Laboratory rats

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