Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

Article Abstract:

The T cells from pancreatic draining lymph nodes, the site of islet-cell-specific self-antigen presentation, are examined. The results identify insulin-reactive, clonally expanded T cells from the site of autoinflammatory drainage in long-term type 1 diabetics, indicating that insulin may indeed be the target antigen causing autoimmune diabetes.

Author: Hafler, David A., Hering, Bernhard J., Ricordi, Camillo, Kent, Sally C., Yahua Chen, Bregoli, Lisa, Clemmings, Sue M., Kenyon, Norma Sue
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Care and treatment, Type 1 diabetes, Pancreatic diseases

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Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

Article Abstract:

The presence and importance of macrophages on the floor of subcapsular sinus (SCS) and in the medulla of lymph nodes in clearing lymph-borne viruses are demonstrated. These macrophages are found to be extremely useful in initiating humoral immune responses.

Author: von Andrian, Ulrich H., Shayakhmetov, Dmitry M., Massberg, Steffen, Junt, Tobias, Mempel, Thorsten R., Henrickson, Sarah E., Lang, Philipp A., Iannacone, Matteo, Boes, Marianne, Fink, Katja, Di Paolo, Nelson C., Whelan, Sean P.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Diagnosis, Macrophages, Sinusitis, Lymphatic diseases, Medulla oblongata

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T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

Article Abstract:

The phenotype of injected dendritic cells (DCs) that migrated to draining lymph nodes (LNs) is examined. Primary T-cell responses in LNs require contactdependent information exchange between T cells and DCs.

Author: Mempel, Thorsten R., Henrickson, Sarah E., Von Andrian, Ulrich H.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
United States, Cell research, Cytological research, Lymph nodes

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Subjects list: Research, T cells
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