Fat rats and carcinogenesis screening: it is poor science to use inappropriate strains of rodents in badly design and inefficient experiments for testing the safety of chemicals
Article Abstract:
It is important to use isogenic laboratory animals in chemical toxicity testing, but most toxicologists use inappropriate outbred strains of rodents, which often die before tests for long term toxicity are completed. Outbred stocks change over time due to mutation, genetic drift and directional selection, whereas isogenic strains are produced by brother/sister matings and seen as immortal clones of genetically identical individuals.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Mighty mice: Clarence Little's brainwave gave biomedical researchers their best friend
Article Abstract:
The inbred, or 'isogenic,' mouse strains produced by Clarence Cook Little proved extremely influential. Little was particularly influential in founding the Roscoe B. Jackson Memorial Laboratory in 1929.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Functional annotation of a full-length mouse cDNA collection
Article Abstract:
Research is presented concerning the determination of the full coding of the genome of a mouse. The methods used during the project and the establishment of the RIKEN clone collection are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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