Genetic modification of heterochromatic association and nuclear organization in Drosophila

Article Abstract:

The insertion of heterochromatin into a euchromatic gene causes position-effect variegation in Drosophila melanogaster. The insertion also results in association of the gene with heterochromatin. Proteins responsible for the formation of heterochromatin affect the interphase nuclear position of a chromosomal region. Heterochromatin and the proteins offer a structural framework for the interphase nucleus. A study uses fluorescent in situ hybridization to interphase diploid nuclei.

Physiological aspects, Genetic aspects, Proteins, Mutation (Biology), Mutation, Drosophila

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A highly active synthetic mammalian retrotransposon

Article Abstract:

Bypassing of the transcription through L1 defect by synthesizing the open reading frames of L1 from synthetic oligonucleotides, altering 24% of the nucleic acid sequence without changing the amino acid sequence is reported. Further a comparison between the activity of the synthetic mouse l1 retrotransposons with wild-type human and mouse L1 in mouse cells is presented.

Nucleic acids, Retrotransposons, Nucleic acid synthesis

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Versatile assembler

Article Abstract:

The versatility and the role of WD-40, the penetrating oil, in maintaining stability during development is discussed. The importance and use of this component required by protein machines is explained.

Protein research

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