Genetic organization of a chimpanzee lentivirus related to HIV-1

Article Abstract:

Viruses that are similar to HIV 1 (human immunodeficiency virus, type 1), which causes AIDS (autoimmune deficiency syndrome), have been isolated from various strains of monkeys and other animals. These are called simian immunodeficiency viruses (SIV), and are acutally more closely related to HIV 2, which doesn't cause AIDS, than HIV 1. Recently a simian virus that more closely resembles HIV 1 has been demonstrated. They call this virus SIV (subscript cpz), and, although similar to HIV 1 in its overall genetic organization, it was found to represent yet another of the many distinct simian lentiviruses believed to exist. This was concluded because of the many divergent proteins that emerged during coding of the genetic material, and these findings are discussed in detail in the article. (Consumer Summary produced by Reliance Medical Information, Inc.)

Diseases, Genetic aspects, Origin, Chimpanzees, Simian immunodeficiency virus

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One on one meets two

Article Abstract:

The entry of HIV into the host cells is aided by the transmembrane and surface proteins, gp120 and gp41, respectively. They are the enzyme-cleavaged products of an HIV-encoded glycoprotein precursor, gp160. The surface protein gp120 recognizes the host CD4 receptor and undergoes a transformational change allowing it to bind to the second receptor, CCR-5. The amino terminus of gp41 is exposed and the host cell membrane is penetrated by the HIV. HIV penetration of host cells even in the absence of CD-4 cells occurs probably due to genetic complexity of high-titre virus numbers.

Research, HIV infection, HIV infections, Virus receptors

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Down or out in blood and lymph?

Article Abstract:

Research scientists now believe that a full-blown human immunodeficiency virus (HIV) infection can be destroyed within three years though the use of multiple drug treatment. The combined usage of HIV inhibitors such as the protease inhibitor nelfinavir with extant pharmaceuticals to oppose viral reverse transcriptase appears to be very effective at systematically reducing the number of infections HIV virions in the bloodstream.

Care and treatment, Usage, Prevention, AIDS patients, Drug therapy, Combination, Combination drug therapy

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