Abstracts » Zoology and wildlife conservation

Halogen lamp carcinogenicity

Article Abstract:

Uncovered quartz halogen lamps have been identified as a source of carcinogenic ultraviolet light. The lights' genotoxicity was proven through the mutagenicity test in his- Salmonella typhimurium and a DNA repair test in Escherichia coli. Moreover, the testing showed that halogen lamps produce ultraviolet radiation at wavelengths that cause melanoma. A study with animal models has so far confirmed the in vitro studies' results. The mandatory use of glass or plastic covers to block the emission of harmful light from halogen lamps is advisable.

Health aspects, Lamps, Ultraviolet radiation, Halogens, Halogen elements

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Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

Article Abstract:

The loss of the tumor suppressor p16 or the retinoblastoma protein (RB), and overexpression of D-type cyclins have identical effects on the G1 progression of cell cycle. In the late G1, the wild-type p16 stops the development of diploid cells but the p16 tumour-associated mutant does not. The interaction of the cyclin-dependent kinases 4 and 6 with the missense mutations in p16 support the development of tumor cells thereby causing the inactivation of RB.

Retinoblastoma

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Hypomethlation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis

Article Abstract:

Tamoxifen and oestrogen have distinct but overlapping target gene profiles, and a paired box gene, PAX2 that is crucially involved in cell proliferation and carciogenesis in the endometrium is identified in overlapping target genes. Experiments show that PAX2 is activated by oestrogen and tamoxifen in endometrial carcinomas but not in normal endometrium and this activation is associated with cancer-linked hypomethylation of the PAX2 promotor.

United States, Science & research, Endometrial cancer

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