Abstracts - faqs.org

Abstracts

Zoology and wildlife conservation

Search abstracts:
Abstracts » Zoology and wildlife conservation

Highly efficient endogenous human gene corrections using designed zinc-finger nucleases

Article Abstract:

A general solution is reported using two fundamental biological processes of DNA recognition by C2H2 zinc-finger proteins and homology-directed repair of DNA double-strand breaks. The zinc finger nucleases designed against an X-linked severe combined immune deficiency mutation in the IL2R gamma gene yielded more than 18% gene-modified human cells without selection.

Author: Urnov, Fyodor D., Miller, Jeffrey C., Ya-Li Lee, Beausejour, Christian M., Rock, Jeremy M., Augustus, Sheldon, Jamieson, Andrew C., Porteus, Mattew H., Gregory, Philip D., Holmes, Michael C.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Zinc finger proteins

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

Balancing regeneration and cancer

Article Abstract:

Stem/progenitor-cell proliferation, despite ensuring the benefits of tissue repair and regeneration, also adversely affect tissues by often putting them at risk of hyperproliferative diseases, the most deadly of which is cancer. Scientists have found out that the tumor-suppression protein [p16.sup.INK4a] can mitigate such risk.

Author: Campisi, Judith, Beausejour, Christian M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
United Kingdom, Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Cancer & Cell R&D, Aging, Cancer research, Muscles, Cancer, Oncology, Experimental, Muscle regeneration, Aging (Biology)

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

The DNA sequence and biological annotation of human chromosome 1

Article Abstract:

The finished sequence and biological annotation of human chromosome is reported. Patterns of sequence variation reveal signals of recent selection in specific genes that may contribute to human fitness and also in regions where no function is evident.

Author: Evans, R., Dunham, A., Jones, M.C., Scott, C.E., Howe, K.L., Barlow, K.F., Searle, S., Y. Zhou, Gregory, S.G., McLay, K.E., Kaul , R., Swarbreck, D., Woodfine, K., Spencer, C.C.A., Gillson, C., Kokocinski, F., McDonald, L., Phillips, K., Atkinson, A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Nucleotide sequence, Base sequence

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, Human genetics, Human chromosomes
Similar abstracts:
  • Abstracts: US set to endorse human pesticide testing. Foreign students face extra UK security checks. Ban on triazine herbicides likely to reduce but not negate relative benefits of GMHT maize cropping
  • Abstracts: Universities urged to do more for poor nations. Heightened security after flu scare sparks biosafety debate
  • Abstracts: Enhancing semiconductor device performance using ordered dopant arrays
  • Abstracts: Wall Street's gradual green revolution. A garden for all climates. Car emissions are EPA's problem
  • Abstracts: AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis. Auxin action
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2025 Advameg, Inc.