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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Highly efficient endogenous human gene corrections using designed zinc-finger nucleases

Article Abstract:

A general solution is reported using two fundamental biological processes of DNA recognition by C2H2 zinc-finger proteins and homology-directed repair of DNA double-strand breaks. The zinc finger nucleases designed against an X-linked severe combined immune deficiency mutation in the IL2R gamma gene yielded more than 18% gene-modified human cells without selection.

Author: Urnov, Fyodor D., Miller, Jeffrey C., Ya-Li Lee, Beausejour, Christian M., Rock, Jeremy M., Augustus, Sheldon, Jamieson, Andrew C., Porteus, Mattew H., Gregory, Philip D., Holmes, Michael C.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Zinc finger proteins

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Balancing regeneration and cancer

Article Abstract:

Stem/progenitor-cell proliferation, despite ensuring the benefits of tissue repair and regeneration, also adversely affect tissues by often putting them at risk of hyperproliferative diseases, the most deadly of which is cancer. Scientists have found out that the tumor-suppression protein [p16.sup.INK4a] can mitigate such risk.

Author: Campisi, Judith, Beausejour, Christian M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
United Kingdom, Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Cancer & Cell R&D, Aging, Cancer research, Muscles, Cancer, Oncology, Experimental, Muscle regeneration, Aging (Biology)

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The DNA sequence and biological annotation of human chromosome 1

Article Abstract:

The finished sequence and biological annotation of human chromosome is reported. Patterns of sequence variation reveal signals of recent selection in specific genes that may contribute to human fitness and also in regions where no function is evident.

Author: Evans, R., Dunham, A., Jones, M.C., Scott, C.E., Howe, K.L., Barlow, K.F., Searle, S., Y. Zhou, Gregory, S.G., McLay, K.E., Kaul , R., Swarbreck, D., Woodfine, K., Spencer, C.C.A., Gillson, C., Kokocinski, F., McDonald, L., Phillips, K., Atkinson, A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Nucleotide sequence, Base sequence

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Subjects list: Research, Human genetics, Human chromosomes
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