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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1

Article Abstract:

An analysis attempts to show that the chaperone protein Hsp70 protects the transcription factor GATA-1 from caspase-mediated proteolysis during differentiation, but not during apoptosis. The findings have shown that in erythroid precursors undergoing terminal differentiation, Hsp70 prevents the active caspase-3 from cleaving GATA-1 and inducing apoptosis.

Author: Varet, Bruno, Solary, Eric, Moura, Ivan Cruz, Ribeil, Jean-Antoine, Zermati, Yael, Vandekerckhove, Julie, Cathelin, Severine, Kersual, Joelle, Dussiot, Michael, Coulon, Severine, Zeuner, Ann, Kirkegaard-Sorensen, Thomas, Carrido, Carmen, Hermine, Olivier
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
France, Proteolysis, Erythropoiesis

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BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

Article Abstract:

The application of the brainspecific angiogenesis inhibitor 1 (BAI1) as a receptor of the ELMO/Dock180/Rac proteins is discussed. The results show that BAI1 can also be used for binding phosphatidylserine on apoptotic cells.

Author: Elliott, Michael R., Tosello-Trampont, Annie-Carole, Haney, Lisa B., Ravichandran, Kodi S., Park, Daeho, Mingjian Lu, Zhong Ma, Klibanov, Alexander L., Mandell, James W.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
G proteins, Angiogenesis inhibitors

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Identification of Tim4 as a phosphatidylserine receptor

Article Abstract:

The importance of the type I transmembrane protein, Tim4 as a phosphatidylserine receptor for binding apoptotic cells is discussed. The protein is also found to be very useful in the intercellular signalling of exosomes.

Author: Uchiyama, Yasuo, Nagata, Shigekazu, Kitamura, Toshio, Koike, Masato, Miyanishi, Masanori, Tada, Kazutoshi
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Membrane proteins, Cellular signal transduction

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Subjects list: Research, Analysis, Apoptosis
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