Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
Article Abstract:
An analysis attempts to show that the chaperone protein Hsp70 protects the transcription factor GATA-1 from caspase-mediated proteolysis during differentiation, but not during apoptosis. The findings have shown that in erythroid precursors undergoing terminal differentiation, Hsp70 prevents the active caspase-3 from cleaving GATA-1 and inducing apoptosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
Article Abstract:
The application of the brainspecific angiogenesis inhibitor 1 (BAI1) as a receptor of the ELMO/Dock180/Rac proteins is discussed. The results show that BAI1 can also be used for binding phosphatidylserine on apoptotic cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Identification of Tim4 as a phosphatidylserine receptor
Article Abstract:
The importance of the type I transmembrane protein, Tim4 as a phosphatidylserine receptor for binding apoptotic cells is discussed. The protein is also found to be very useful in the intercellular signalling of exosomes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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