Insensitivity to anaesthetic agents conferred by a class of GABA(sub A) receptor subunit

Article Abstract:

General anaesthetic agents normally can potentiate neuronal inhibition through GABA(sub A) or gamma-aminobutyric acid receptors. There is sufficient evidence indicating that these receptors are heterogeneously sensitive to anaesthetic agents, although the structural causes of the variations are still unclear. A new class of GABA(sub A) receptor, subunit epsilon, is identified. It is found to have the ability to assemble with alpha- and beta-subunits. Results also indicate that its presence has a significant impact on the sensitivity of GABA(sub A) receptors to intravenous anaesthetic agents. Other findings are discussed.

GABA, GABA receptors, Anesthetics

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The 5-HT 3b subunit is a major determinant of serotonin-receptor function

Article Abstract:

The neurotransmitter serotonin (50HT) leads to rapid excitatory responses via ligand-gated channels. Neuronal 5-HT 3 receptors show a permeability to calcium ions and a current-voltage link differing from that of homomeric receptors. A new class of 5-HT3-receptor subunit (5-HT3B) is described. The heteromeric receptors exhibit distinctive pharmacological properties. The 5-HT3B subunit will be a useful resource to define the molecular mechanisms of ion-channel function.

Serotonin, Serotonin receptors

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A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

Article Abstract:

A determinant of single-channel conductance that can explain observations of 5-Hydroxytryptamine type 3 (5-HT3) receptors are described. 5-HT3 receptors are cation selective transmitter-gated ion channels of the Cys-loop superfamily.

Science & research, Cytoplasm

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