Abstracts » Zoology and wildlife conservation

Lifespan of human lymphocyte subsets defined by CD45 isoforms

Article Abstract:

A study was conducted to determine whether immunological memory depends upon antigen recognition by individual long-lived T-cells or by their long-lived clones. The T-cell expression of the isoform of CD45 known as CD45R0 contains the memory cells while the isoform known as CD45RA is naive. These isoforms were studied after patient radiotherapy and the CD45R0 pool rapidly lost unstable chromosomes while the CD45A pool did not. This indicates the CD45R0 memory cells divide more rapidly than naive cells and the data suggest some reversion to the naive form. Memory must therefore be carried by clones.

Molecular biology, Immune response, Immune recognition

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Endogenous superantigen expression controlled by a novel promoter in the MMTV long terminal repeat

Article Abstract:

A study of a novel promoter situated upstream from the mouse mammary tumour virus promoter showed that the new U3 promoter enables the manifestation of the superantigen directly when the MMTV promoter is not present, and is active in B lymphocytes, which are cognate antigen-presenting cells for endogenous superantigen. The promoter is located in the endogenous superantigens, encoded by the open reading flame contained within MMTV long terminal repeat (LTR).

Analysis, Oncogenic viruses, Antigens

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Evidence for a viral superantigen in humans

Article Abstract:

The rabies virus' nucleocapsid functions as an exogenous superantigen for V-beta-8 human T lymphocytes; in this role the nucleocapsid links with HLA class II-alpha chains. This is the first time that the exact nature of a viral superantigen has been verified in humans. Superantigens are responsible for binding class II major histocompatibility proteins and for engendering a strong growth response in T lymphocytes.

Rabies, Viral antigens

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