Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Article Abstract:
Thyroid-hormone and retinoic-acid receptors, attached to the retinoid-X receptor as heterodimers to cognate DNA positions, mediate ligand-independent transcriptional repression by effecting both positive and negative gene expression when their ligands are present or absent. A 270 K protein, named the nuclear receptor co-repressor, mediates ligand-independent transcriptional repression similar to the processes in yeast and Drosophila.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
Article Abstract:
The significance of SMRT in repressing the progression of a histone H3 trimethyl K27 demethylase from a neural stem cell to neuron is explained. SMRT is also found to be extremely important in the forebrain development phenomenon.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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